سوال بسيط لو تكرمتو.. Bioc201

[R-Kh]

The major isoform of the human growth hormone is a protein of 191 amino acids and a molecular weight of 22,124 daltons. The structure includes four helices necessary for functional interaction with the GH receptor. It appears that, in structure, GH is evolutionarily homologous to prolactin and chorionic somatomammotropin. Despite marked structural similarities between growth hormone from different species, only human and primate growth hormones have significant effects in humans.

Several molecular isoforms of GH circulate in the plasma. A percentage of the growth hormone in the circulation is bound to a protein (growth hormone-binding protein, GHBP) which is the truncated part of the growth hormone receptor, and an acid labile subunit (ALS).